Au⋅⋅⋅H-C Hydrogen Bonds as Design Principle in Gold(I) Catalysis.

ABSTRACT: Secondary ligand-metal interactions are decisive in many catalytic transformations. While arene-gold interactions have repeatedly been reported as critical structural feature in many high-performance gold catalysts, we herein report that these interactions can also be replaced by Au⋅⋅⋅H-C hydrogen bonds without suffering any reduction in catalytic performance. Systematic experimental and computational studies on a series of ylide-substituted phosphines featuring either a PPh₃ (^Ph YPhos) or PCy₃ (^Cy YPhos) moiety showed that the arene-gold interaction in the aryl-substituted compounds is efficiently compensated by the formation of Au⋅⋅⋅H-C hydrogen bonds. The strongest interaction is found with the C-H moiety next to the onium center, which due to

SUBMITTER: Darmandeh H 

PROVIDER: S-EPMC8518757 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature