Hepatocellular adenoma in men: A nationwide assessment of pathology and correlation with clinical course.

ABSTRACT:

Background & aims

Hepatocellular adenomas (HCA) rarely occur in males, and if so, are frequently associated with malignant transformation. Guidelines are based on small numbers of patients and advise resection of HCA in male patients, irrespective of size or subtype. This nationwide retrospective cohort study is the largest series of HCA in men correlating (immuno)histopathological and molecular findings with the clinical course.

Methods

Dutch male patients with available histological slides with a (differential) diagnosis of HCA between 2000 and 2017 were identified through the Dutch Pathology Registry (PALGA). Histopathology and immunohistochemistry according to international guidelines were revised by two expert hepatopathologists. Next generation sequencing (NGS) was per

SUBMITTER: van Rosmalen BV 

PROVIDER: S-EPMC8518832 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature