Long-Term Observational Results from the ASPIRE Study: OnabotulinumtoxinA Treatment for Adult Lower Limb Spasticity.

ABSTRACT:

Introduction

OnabotulinumtoxinA treatment for spasticity varies according to numerous factors and is individualized to meet treatment goals.

Objective

To explore real-world onabotulinumtoxinA utilization and effectiveness in patients with lower limb spasticity from the Adult Spasticity International Registry (ASPIRE) study.

Design

Two-year, multicenter, prospective, observational registry (NCT01930786).

Setting

Fifty-four international clinical sites.

Patients

Adults (naïve or non-naïve to botulinum toxin[s] treatment for spasticity, across multiple etiologies) with lower limb spasticity related to upper motor neuron syndrome.

Interventions

OnabotulinumtoxinA administered at the clinician's discretion.

Main outcome measures

Onabotulinumtoxi

SUBMITTER: Esquenazi A 

PROVIDER: S-EPMC8519010 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature