Liraglutide pharmacokinetics and exposure-response in adolescents with obesity.

ABSTRACT:

Background

Obesity in adolescence presents a major public health challenge, often leading to obesity in adulthood with associated chronic disease.

Objectives

This study aimed to perform a population pharmacokinetic and exposure-response analysis of liraglutide by meta-analysis of data from trials conducted in children, adolescents and adults with obesity.

Methods

The population pharmacokinetic analysis investigated the effect of covariates body weight, age group (children, adolescents and adults) and sex on liraglutide exposure in adolescents compared with previous results in adults. The exposure-response relationship of liraglutide for the change from baseline in body mass index standard deviation score (BMI SDS) was evaluated in adolescents and compared to that in a

SUBMITTER: Carlsson Petri KC 

PROVIDER: S-EPMC8519033 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature