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A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines.

ABSTRACT: We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO₂ CF₃ groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.

SUBMITTER: Lazaro-Milla C

PROVIDER: S-EPMC8519061 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines.

Lázaro-Milla Carlos C Almendros Pedro P

Chemistry (Weinheim an der Bergstrasse, Germany) 20210810 54

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO<sub>2</sub> CF<sub>3</sub> groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups. ...[more]

PMID: 34369000

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