AMYQ: An index to standardize quantitative amyloid load across PET tracers.

ABSTRACT:

Introduction

Positron emission tomography (PET) amyloid quantification methods require magnetic resonance imaging (MRI) for spatial registration and a priori reference region to scale the images. Furthermore, different tracers have distinct thresholds for positivity. We propose the AMYQ index, a new measure of amyloid burden, to overcome these limitations.

Methods

We selected 18F-amyloid scans from ADNI and Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) with the corresponding T1-MRI. A subset also had neuropathological data. PET images were normalized, and the AMYQ was calculated based on an adaptive template. We compared AMYQ with the Centiloid scale on clinical and neuropathological diagnostic performance.

Results

AMYQ was related with amy

SUBMITTER: Pegueroles J 

PROVIDER: S-EPMC8519100 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature