Transcriptomic Signatures Associated With Regional Cortical Thickness Changes in Parkinson's Disease.

ABSTRACT: Cortical atrophy is a common manifestation in Parkinson's disease (PD), particularly in advanced stages of the disease. To elucidate the molecular underpinnings of cortical thickness changes in PD, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas and patterns of cortical thickness based on T1-weighted anatomical MRI data of 149 PD patients and 369 controls. For this purpose, we used partial least squares regression to identify gene expression patterns correlated with cortical thickness changes. In addition, we identified gene expression patterns underlying the relationship between cortical thickness and clinical domains of PD. Our results show that genes whose expression in the healthy brain is associated with cortical thickness

SUBMITTER: Keo A 

PROVIDER: S-EPMC8519261 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature