Ontology highlight
ABSTRACT:
SUBMITTER: Barredo PA
PROVIDER: S-EPMC8519458 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Barredo Prechiel A PA Fernandez Marvin Jose F MJF Ambe Christopher E CE Balanay Mannix P MP
PloS one 20211015 10
The microtubule-binding protein tau has been the center of researches concerning Alzheimer's disease (AD) due to several clinical trials of β-amyloid therapies failing recently. The availability of the tau fibril structure from AD brain enables computational modeling studies to calculate binding affinities with different ligands. In this study, the tau paired helical filaments (PHF-Tau) (PDB ID: 5O3L) was used as receptor and interactions with the lipids: 3-alpha-cholesterol; 1-palmitoyl-2-oleoy ...[more]