Personality changes with subcallosal cingulate deep brain stimulation in patients with treatment-resistant depression.

ABSTRACT:

Background

Deep brain stimulation (DBS) is a promising investigational approach for treatment-resistant depression. However, reports suggesting changes in personality with DBS for movement disorders have raised clinical and ethical concerns. We prospectively examined changes in personality dimensions and antidepressant response to subcallosal cingulate (SCC)-DBS for treatment-resistant depression.

Methods

Twenty-two patients with treatment-resistant depression underwent SCC-DBS. We used the NEO Five-Factor Inventory for personality assessment at baseline and every 3 months until 15 months post-DBS. We assessed depression severity monthly using the Hamilton Depression Rating Scale.

Results

We found a significant decrease in neuroticism (p = 0.002) and an increas

SUBMITTER: Ramasubbu R 

PROVIDER: S-EPMC8519494 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature