Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting.

ABSTRACT: Hydrogel microparticles (HMPs) are an emerging bioink that can allow three-dimensional (3D) printing of most soft biomaterials by improving physical support and maintaining biological functions. However, the mechanisms of HMP jamming within printing nozzles and yielding to flow remain underexplored. Here, we present an in-depth investigation via both experimental and computational methods on the HMP dissipation process during printing as a result of (i) external resistance from the printing apparatus and (ii) internal physicochemical properties of HMPs. In general, a small syringe opening, large or polydisperse size of HMPs, and less deformable HMPs induce high resistance and closer HMP packing, which improves printing fidelity and stability due to increased interparticle adhesion. However

SUBMITTER: Xin S 

PROVIDER: S-EPMC8519565 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature