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Retrospective pharmacogenetic analysis of a pediatric patient under anticoagulant treatment: Clinical case


ABSTRACT: We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, forcing the discontinuation and restart of treatment more than once. Expected and stable INR levels were achieved after more than 30 days of treatment, surprisingly with half the recommended dose for a patient of her age and weight.

SUBMITTER: Cavieres M 

PROVIDER: S-EPMC8519589 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Retrospective pharmacogenetic analysis of a pediatric patient under anticoagulant treatment: Clinical case

Cavieres Mirta M   Suárez Marcelo M   Verón Gabriel G   Quiñones Luis Abel LA   Varela Nelson Miguel NM  

Biomedica : revista del Instituto Nacional de Salud 20210922 3


We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, forcing the discontinuation and restart of treatment more than once. Expected and stable INR levels were achieved after more than 30 days of treatment, surprisingly with half the recommended dose for a patient of her age and weight. We decided to conduct a retrospective phar  ...[more]

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