Novel characterization of the relationship between verbal list-learning outcomes and hippocampal subfields in healthy adults.

ABSTRACT: The relationship between hippocampal subfield volumetry and verbal list-learning test outcomes have mostly been studied in clinical and elderly populations, and remain controversial. For the first time, we characterized a relationship between verbal list-learning test outcomes and hippocampal subfield volumetry on two large separate datasets of 447 and 1,442 healthy young and middle-aged adults, and explored the processes that could explain this relationship. We observed a replicable positive linear correlation between verbal list-learning test free recall scores and CA1 volume, specific to verbal list learning as demonstrated by the hippocampal subfield volumetry independence from verbal intelligence. Learning meaningless items was also positively correlated with CA1 volume, pointing to t

SUBMITTER: Cremona S 

PROVIDER: S-EPMC8519870 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature