Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.

ABSTRACT: Obesity imposes serious health risks and involves alterations in resting-state functional connectivity of brain networks involved in eating behavior. Bariatric surgery is an effective treatment, but its effects on functional connectivity are still under debate. In this pre-registered study, we aimed to determine the effects of bariatric surgery on major resting-state brain networks (reward and default mode network) in a longitudinal controlled design. Thirty-three bariatric surgery patients and 15 obese waiting-list control patients underwent magnetic resonance imaging at baseline, after 6 and 12 months. We conducted a pre-registered whole-brain time-by-group interaction analysis, and a time-by-group interaction analysis on within-network connectivity. In exploratory analyses, we investiga

SUBMITTER: Heinrichs HS 

PROVIDER: S-EPMC8519880 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature