Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.

ABSTRACT: Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms and testing interventions and therapeutics. For disorders such as Alzheimer's disease in which numerous models are being generated, a challenging first step is to identify the most appropriate model and age to effectively evaluate new therapeutic approaches. Here we conducted a detailed phenotypic characterization of the 5xFAD model on a congenic C57BL/6 J strain background, across its lifespan - including a seldomly analyzed 18-month old time point to provide temporally correlated phenotyping of this model and a template for characterization of new models of LOAD as they are generated. This comprehensive analysis included quantification of plaque burden, Aβ biochemical levels, and neuropathology, neurop

SUBMITTER: Forner S 

PROVIDER: S-EPMC8519958 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature