The δ subunit of F₁F_o-ATP synthase is required for pathogenicity of Candida albicans.

ABSTRACT: Fungal infections, especially candidiasis and aspergillosis, claim a high fatality rate. Fungal cell growth and function requires ATP, which is synthesized mainly through oxidative phosphorylation, with the key enzyme being F₁F_o-ATP synthase. Here, we show that deletion of the Candida albicans gene encoding the δ subunit of the F₁F_o-ATP synthase (ATP16) abrogates lethal infection in a mouse model of systemic candidiasis. The deletion does not substantially affect in vitro fungal growth or intracellular ATP concentrations, because the decrease in oxidative phosphorylation-derived ATP synthesis is compensated by enhanced glycolysis. However, the ATP16-deleted mutant displays decreased phosphofructokinase activity, leading to low fructose 1,6-bispho

SUBMITTER: Li S 

PROVIDER: S-EPMC8519961 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature