Short-duration dynamic [¹⁸F]DCFPyL PET and CT perfusion imaging to localize dominant intraprostatic lesions in prostate cancer: validation against digital histopathology and comparison to [¹⁸F]DCFPyL PET/MR at 120 minutes.

ABSTRACT:

Purpose

Localized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy through more precise targeting of biopsy, radiotherapy and focal ablative therapies. The goal of this study is to validate the performance of [¹⁸F]DCFPyL PET and CT perfusion (CTP) for detecting and localizing DIL against digital histopathological images.

Methods

Multi-modality image sets: in vivo T2-weighted (T2w)-MRI, 22-min dynamic [¹⁸F]DCFPyL PET/CT, CTP, and 2-h post-injection PET/MR were acquired in patients prior to radical prostatectomy. The explanted gland with implanted fiducial markers was imaged with T2w-MRI. All images were co-r

SUBMITTER: Yang DM 

PROVIDER: S-EPMC8519985 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature