MiR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is one of the most common malignancy in the world. It has been reported that cancer stem cells (CSCs) serve as the primary drivers of tumorigenesis and tumor progression. There is an urgent need to explore novel molecules that regulate CSCs or their signatures. Increasing evidence has shown that miRNAs are involved in tumorigenesis and progression. Here, we aim to explore the regulatory effect and mechanism of miR-3065-3p on the stemness of colorectal cancer.

Methods

The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases. Gain or loss of function in different models, including colorectal cancer cell lines

SUBMITTER: Li Y 

PROVIDER: S-EPMC8520297 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature