Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children.

ABSTRACT:

Background

Metabolic syndrome increases the risk of cardiovascular disease in adults. Antecedents likely begin in childhood and whether childhood exposure to air pollution plays a contributory role is not well understood.

Objectives

To assess whether children's exposure to air pollution is associated with markers of risk for metabolic syndrome and oxidative stress, a hypothesized mediator of air pollution-related health effects.

Methods

We studied 299 children (ages 6-8) living in the Fresno, CA area. At a study center visit, questionnaire and biomarker data were collected. Outcomes included hemoglobin A1c (HbA1c), urinary 8-isoprostane, systolic blood pressure (SBP), and BMI. Individual-level exposure estimates for a set of four pollutants that are constituents of tr

SUBMITTER: Mann JK 

PROVIDER: S-EPMC8520413 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature