Early life adoption shows rearing environment supersedes transgenerational effects of paternal stress on aggressive temperament in the offspring.

ABSTRACT: Prenatal experience and transgenerational influences are increasingly recognized as critical for defining the socio-emotional system, through the development of social competences and of their underlying neural circuitries. Here, we used an established rat model of social stress resulting from male partner aggression induced by peripubertal (P28-42) exposure to unpredictable fearful experiences. Using this model, we aimed to first, characterize adult emotionality in terms of the breadth of the socio-emotional symptoms and second, to determine the relative impact of prenatal vs postnatal influences. For this purpose, male offspring of pairs comprising a control or a peripubertally stressed male were cross-fostered at birth and tested at adulthood on a series of socio-emotional tests. In the

SUBMITTER: Zutshi I 

PROVIDER: S-EPMC8520526 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature