Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials.

ABSTRACT:

Background

Vascular prevention trials typically use dichotomous event outcomes although this may be inefficient statistically and gives no indication of event severity. We assessed whether ordinal outcomes would be more efficient and how to best analyse them.

Methods

Chief investigators of vascular prevention randomised controlled trials that showed evidence of either benefit or harm, or were included in a systematic review that overall showed benefit or harm, shared individual participant data from their trials. Ordered categorical versions of vascular event outcomes (such as stroke and myocardial infarction) were analysed using 15 statistical techniques and their results then ranked, with the result with the smallest p-value given the smallest rank. Friedman and Duncan's m

SUBMITTER: Woodhouse LJ 

PROVIDER: S-EPMC8520648 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature