Extracellular vesicles: mediators of intercellular communication in tissue injury and disease.

ABSTRACT: Intercellular communication is a critical process that ensures cooperation between distinct cell types and maintains homeostasis. EVs, which were initially described as cellular debris and devoid of biological function, are now recognized as key components in cell-cell communication. EVs are known to carry multiple factors derived from their cell of origin, including cytokines and chemokines, active enzymes, metabolites, nucleic acids, and surface molecules, that can alter the behavior of recipient cells. Since the cargo of EVs reflects their parental cells, EVs from damaged and dysfunctional tissue environments offer an abundance of information toward elucidating the molecular mechanisms of various diseases and pathological conditions. In this review, we discuss the most recent findings r

SUBMITTER: Berumen Sanchez G 

PROVIDER: S-EPMC8520651 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature