A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma.

ABSTRACT:

Background

Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk. However, the prognostic value of pyroptosis-associated gene signatures in CM remains unclear.

Methods

Gene profiles and clinical data of patients with CM were downloaded from The Cancer Genome Atlas (TCGA) to identify differentially expressed genes associated with pyroptosis and overall survival (OS). We constructed a prognostic gene signature using LASSO analysis, then applied immune cell infiltration scores and Kaplan-Meier, Cox, and pathway enrichment analyses to determine the roles of the gene signature in CM. A validation cohort was collected from the Gene Expre

SUBMITTER: Wu Z 

PROVIDER: S-EPMC8520690 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature