Late-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.

ABSTRACT: Protein quality control mechanisms decline during the process of cardiac aging. This enables the accumulation of protein aggregates and damaged organelles that contribute to age-associated cardiac dysfunction. Macroautophagy is the process by which post-mitotic cells such as cardiomyocytes clear defective proteins and organelles. We hypothesized that late-in-life exercise training improves autophagy, protein aggregate clearance, and function that is otherwise dysregulated in hearts from old vs. adult mice. As expected, 24-month-old male C57BL/6J mice (old) exhibited repressed autophagosome formation and protein aggregate accumulation in the heart, systolic and diastolic dysfunction, and reduced exercise capacity vs. 8-month-old (adult) mice (all p < 0.05). To investigate the influence of l

SUBMITTER: Cho JM 

PROVIDER: S-EPMC8520717 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature