Multistate model for pharmacometric analyses of overall survival in HER2-negative breast cancer patients treated with docetaxel.

ABSTRACT: The aim of this study was to develop a multistate model for overall survival (OS) analysis, based on parametric hazard functions and combined with an investigation of predictors derived from a longitudinal tumor size model on the transition hazards. Different states - stable disease, tumor response, progression, second-line treatment, and death following docetaxel treatment initiation (stable state) in patients with HER2-negative breast cancer (n = 183) were used in model building. Past changes in tumor size prospectively predicts the probability of state changes. The hazard of death after progression was lower for subjects who had longer treatment response (i.e., longer time-to-progression). Young age increased the probability of receiving second-line treatment. The developed multistate m

SUBMITTER: Krishnan SM 

PROVIDER: S-EPMC8520749 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature