The Clinical Implications and Molecular Mechanism of CX3CL1 Expression in Urothelial Bladder Cancer.

ABSTRACT:

Background

CX3CL1 is a chemokine that may play important roles in cancer immune regulation. Its mechanism in bladder cancer (BCa) is poorly understood. The objective of the current study was to evaluate the association between CX3CL1 and BCa and the related biological mechanisms.

Methods

A total of 277 patients with BCa were enrolled in the present study. The association between CX3CL1 expression and disease outcome was evaluated. In vitro and in vivo experiments were performed using the TCCSUP cell line to investigate the function of CX3CL1 in BCa.

Results

Compared with low expression, high expression of CX3CL1 was significantly associated with poorer progression-free survival (hazard ratio [HR]=2.03, 95% confidence interval [95% CI]: 1.26-3.27, P=0.006

SUBMITTER: Jiang G 

PROVIDER: S-EPMC8521074 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature