International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing Escherichia coli in Dhaka, Bangladesh.

ABSTRACT: Background: Escherichia coli is a major extended-spectrum β-lactamase (ESBL)-producing organism responsible for the rapid spread of antimicrobial resistance (AMR) that has compromised our ability to treat infections. Baseline data on population structure, virulence, and resistance mechanisms in E. coli lineages from developing countries such as Bangladesh are lacking. Methods: Whole-genome sequencing was performed for 46 ESBL-E. coli isolates cultured from patient samples at the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)-Dhaka. Sequence data were analyzed to glean details of AMR, virulence, and phylogenetic and molecular markers of E. coli lineages. Results: Genome comparison revealed presence of all major hig

SUBMITTER: Mazumder R 

PROVIDER: S-EPMC8521144 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature