Identification of Differential Responses of Goat PBMCs to PPRV Virulence Using a Multi-Omics Approach.

ABSTRACT: Peste des petits ruminants (PPR) is an acute transboundary infectious viral disease of small ruminants, mainly sheep and goats. Host susceptibility varies considerably depending on the PPR virus (PPRV) strain, the host species and breed. The effect of strains with different levels of virulence on the modulation of the immune system has not been thoroughly compared in an experimental setting so far. In this study, we used a multi-omics approach to investigate the host cellular factors involved in different infection phenotypes. Peripheral blood mononuclear cells (PBMCs) from Saanen goats were activated with a T-cell mitogen and infected with PPRV strains of different virulence: Morocco 2008 (high virulence), Ivory Coast 1989 (low virulence) and Nigeria 75/1 (live attenuated vaccine strain).

SUBMITTER: Eloiflin RJ 

PROVIDER: S-EPMC8521192 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature