A multiple sclerosis disease progression measure based on cumulative disability.

ABSTRACT:

Background

Existing severity measurements in multiple sclerosis (MS) are often cross-sectional, making longitudinal comparisons of disease course between individuals difficult.

Objective

The objective of this study is to create a severity metric that can reliably summarize a patient's disease course.

Methods

We developed the nARMSS - normalized ARMSS (age-related MS severity score) over follow-up, using the deviation of individual ARMSS scores from the expected value and integrated over the corresponding time period. The nARMSS scales from -5 to +5; a positive value indicates a more severe disease course for a patient when compared to other patients with similar disease timings.

Results

Using Swedish MS registry data, the nARMSS was tested using data at 2 and 4

SUBMITTER: Manouchehrinia A 

PROVIDER: S-EPMC8521354 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature