Using a public database of Neisseria gonorrhoeae genomes to detect mutations associated with zoliflodacin resistance.

ABSTRACT:

Background

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is an urgent global health threat. Zoliflodacin is a novel antibiotic undergoing clinical trials for the treatment of gonorrhoea. While there are limited data regarding zoliflodacin resistance in N. gonorrhoeae, three amino acid mutations have been associated with increased MICs of zoliflodacin.

Objectives

To determine the prevalence of three amino acid mutations associated with zoliflodacin resistance within a large, public database of nearly 13 000 N. gonorrhoeae genomes.

Methods

PathogenWatch is an online genomic epidemiology platform with a public database of N. gonorrhoeae genomes. That database was used to extract gyrB sequence data and a Basic Local Alignment Search Tool (BLAST) search was perfo

SUBMITTER: Adamson PC 

PROVIDER: S-EPMC8521401 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature