Resting fMRI-guided TMS results in subcortical and brain network modulation indexed by interleaved TMS/fMRI.

ABSTRACT: Traditional non-invasive imaging methods describe statistical associations of functional co-activation over time. They cannot easily establish hierarchies in communication as done in non-human animals using invasive methods. Here, we interleaved functional MRI (fMRI) recordings with non-invasive transcranial magnetic stimulation (TMS) to map causal communication between the frontal cortex and subcortical target structures including the subgenual anterior cingulate cortex (sgACC) and the amygdala. Seed-based correlation maps from each participant's resting fMRI scan determined individual stimulation sites with high temporal correlation to targets for the subsequent TMS/fMRI session(s). The resulting TMS/fMRI images were transformed to quantile responses, so that regions of high-/low-quantil

SUBMITTER: Oathes DJ 

PROVIDER: S-EPMC8521442 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature