Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study.

ABSTRACT:

Background/aims

Proton pump inhibitors (PPIs) increase gastric pH and alter the gut microbiome. An increased risk for infectious diseases has been reported in PPI users. However, little is known about the association of PPI use with pyogenic liver abscess (PLA) incidence risk.

Methods

We conducted a population-based cohort study using data from a nationwide representative sample of the Korean general population followed up for 10 years (January 1, 2003 to December 31, 2013). We identified PPI prescriptions and considered PPI as a timevarying variable. Proportional hazards regression model was used for incident PLA comparing PPI use versus non-use. Propensity score matching was also conducted.

Results

During the 4 209 229 person-years of follow-up, 58 595 participants

SUBMITTER: Oh JH 

PROVIDER: S-EPMC8521470 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature