Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions.

ABSTRACT: Plasticity in multicellular organisms involves signaling pathways converting contexts-either natural environmental challenges or laboratory perturbations-into context-specific changes in gene expression. Congruently, the interactions between the signaling molecules and transcription factors (TF) regulating these responses are also context specific. However, when a target gene responds across contexts, the upstream TF identified in one context is often inferred to regulate it across contexts. Reconciling these stable TF-target gene pair inferences with the context-specific nature of homeostatic responses is therefore needed. The induction of the Caenorhabditis elegans genes lipl-3 and lipl-4 is observed in many genetic contexts and is essential to survival during fasting. We find DAF-16/FOX

SUBMITTER: Mony VK 

PROVIDER: S-EPMC8521664 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature