Dataset Information

XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.

ABSTRACT:

Objective

To investigate the potential correlation between the Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (XRCC2) and colorectal cancer (CRC) risk, as the association remains unclear.

Methods

The CNKI, PubMed, EMBASE and Cochrane library databases were systematically searched for relevant studies published up to July 2021. Data were extracted from included studies, and analysed for pooled or subgroup odds ratios (ORs) with 95% confidence intervals (CIs) using STATA 12.0 software.

Results

Seven published studies were included. Pooled analysis revealed that the XRCC2 Arg188His polymorphism was associated with increased CRC risk (His versus Arg: OR 1.14, 95% CI 1.01, 1.29). Trial Sequential Analysis to test the power of the results showed that they were unreliable and the meta-analysis required additional studies.

Conclusion

The current meta-analysis suggests that the XRCC2 Arg188His polymorphism may be a risk factor for CRC.

SUBMITTER: Wang Z

PROVIDER: S-EPMC8521768 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.

Wang Zhiyu Z Wei Yaning Y An Lin L Xi Chenglin C Wang Kunjie K Hong Dan D Shi Yan Y Zang Aiming A Su Shenyong S Li Wenwen W

The Journal of international medical research 20211001 10

<h4>Objective</h4>To investigate the potential correlation between the Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (<i>XRCC2</i>) and colorectal cancer (CRC) risk, as the association remains unclear.<h4>Methods</h4>The CNKI, PubMed, EMBASE and Cochrane library databases were systematically searched for relevant studies published up to July 2021. Data were extracted from included studies, and analysed for pooled or subgroup odds ratios (ORs) with 95% confidence interv ...[more]

PMID: 34648414

Similar Datasets

Project description:BackgroundAssociation between the single nucleotide polymorphism rs3218536 (known as Arg188His) located in the X-ray repair cross complementing group 2 (XRCC2) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility.MethodsPubMed and Embase databases were searched systematically until September 7, 2013 to obtain all the records evaluating the association between the XRCC2 Arg188His polymorphism and the risk of all types of cancers. We used the odds ratio (OR) as measure of effect, and pooled the data in a Mantel-Haenszel weighed random-effects meta-analysis to provide a summary estimate of the impact of this polymorphism on breast cancer, ovarian cancer and other cancers. All the analyses were carried out in STATA 12.0.ResultsWith 30868 cases and 38656 controls, a total of 45 case-control studies from 26 publications were eventually included in our meta-analysis. No significant association was observed between the XRCC2 Arg188His polymorphism and breast cancer susceptibility (dominant model: OR = 0.94, 95%CI = 0.86-1.04, P = 0.232). However, a significant impact of this polymorphism was detected on decreased ovarian cancer risk (dominant model: OR = 0.83, 95%CI = 0.73-0.95, P = 0.007). In addition, we found this polymorphism was associated with increased upper aerodigestive tract (UADT) cancer susceptibility (dominant model: OR = 1.51, 95%CI = 1.04-2.20, P = 0.032).ConclusionThe Arg188His polymorphism might play different roles in carcinogenesis of various cancer types. Current evidence did not suggest that this polymorphism was directly associated with breast cancer susceptibility. However, this polymorphism might contribute to decreased gynecological cancer risk and increased UADT cancer risk. More preclinical and epidemiological studies were still imperative for further evaluation.

Dataset Information

XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.

Objective

Methods

Results

Conclusion

Publications

XRCC2 Arg188His polymorphism and colorectal cancer risk: a meta-analysis.

Similar Datasets

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