Defer surgery in operable breast cancer: how long is too long?

ABSTRACT:

Purpose

The aim of this meta-analysis was to evaluate outcomes of surgery compared to primary endocrine therapy (PET) in patients with non-advanced, operable invasive breast cancer, and to determine if PET as initial therapy may safely postpone surgery.

Methods

The MEDLINE, EMBASE, PubMed, and Cochrane Library were searched from database inception to July 2020 to identify eligible studies. Inclusion criteria were experimental or observational studies with at least one arm treated with PET and a second arm treated with surgery with or without PET. Local recurrence or progression of disease was defined as either failure of non-operative management (tumor failing to decrease in size and/or continuous local or distant tumor growth) or relapse of breast tumor after tumor downsizi

SUBMITTER: Roberts S 

PROVIDER: S-EPMC8522256 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature