Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians.

ABSTRACT: Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigenous people globally. Although vaccination against influenza is recommended for those most at risk, studies on immune responses elicited by seasonal vaccines in Indigenous populations are largely missing, with no data available for Indigenous Australians and only one report published on antibody responses in Indigenous Canadians. We recruited 78 Indigenous and 84 non-Indigenous Australians vaccinated with the quadrivalent influenza vaccine into the Looking into InFluenza T cell immunity - Vaccination cohort study and collected blood to define baseline, early (day 7), and memory (day 28) immune responses. We performed in-depth analyses of T and B cell activation,

SUBMITTER: Hensen L 

PROVIDER: S-EPMC8522271 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature