A SARS-CoV-2 Delta variant outbreak on airplane: vaccinated air passengers are more protected than unvaccinated.
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ABSTRACT:
SUBMITTER: Lv Q
PROVIDER: S-EPMC8522384 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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A SARS-CoV-2 Delta variant outbreak on airplane: vaccinated air passengers are more protected than unvaccinated.
Lv Qiuying Q Kong Dongfeng D He Yaqing Y Lu Yan Y Chen Long L Zhao Jin J Feng Siyang S Chen Yixiong Y Wan Jia J Wen Ying Y Gao Wei W Chen Zhigao Z Tang Xiujuan X Mei Shujiang S Zou Xuan X Feng Tiejian T
Journal of travel medicine 20211201 8
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Project description:BackgroundUnderstanding the immune response to evolving viral strains is crucial for evidence-informed public health strategies. The main objective of this study is to assess the influence of vaccination on the neutralizing activity of SARS-CoV-2 delta and omicron infection against various SARS-CoV-2 variants.MethodsA total of 97 laboratory-confirmed COVID-19 cases were included. To assess the influence of vaccination on neutralizing activity, we measured the neutralizing activity of SARS-CoV-2 delta or omicron (BA.1 or BA.2) infection against wild-type (WT), delta, BA.1, and BA.2, with the results stratified based on vaccination status.ResultsThe neutralizing activity against the WT, delta, and omicron variants (BA.1 and BA.2) was significantly higher in the vaccinated patients than those in the unvaccinated patients. In the unvaccinated individuals infected with the delta variant, the decrease in binding to BA.1 and BA.2 was statistically significant (3.9- and 2.7-fold, respectively) compared to the binding to delta. In contrast, vaccination followed by delta breakthrough infection improved the cross-neutralizing activity against omicron variants, with only 1.3- and 1.2-fold decreases in BA.1 and BA.2, respectively. Vaccination followed by infection improved cross-neutralizing activity against WT, delta, and BA.2 variants in patients infected with the BA.1 variant, compared to that in unvaccinated patients.ConclusionsVaccination followed by delta or BA.1 infection is associated with improved cross-neutralizing activity against different SARS-CoV-2 variants. The enhanced protection provided by breakthrough infections could have practical implications for optimizing vaccination strategies.
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