Targeting Immune Cell Metabolism in the Treatment of Inflammatory Bowel Disease.

ABSTRACT: The cells of the immune system are highly dynamic, constantly sensing and adapting to changes in their surroundings. Complex metabolic pathways govern leukocytes' ability to fine-tune their responses to external threats. Mammalian target of rapamycin complex 1 and hypoxia inducible factor are important hubs of these pathways and play a critical role coordinating cell activation and proliferation and cytokine production. For this reason, these molecules are attractive therapeutic targets in inflammatory disease. Insight into perturbations in immune cell metabolic pathways and their impact on inflammatory bowel disease (IBD) progression are starting to emerge. However, it remains to be determined whether the aberrations in immune metabolism that occur in gut resident immune cells contribute

SUBMITTER: Zaiatz Bittencourt V 

PROVIDER: S-EPMC8522790 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature