Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months.

ABSTRACT:

Background

Despite high vaccine coverage and effectiveness, the incidence of symptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been increasing in Israel. Whether the increasing incidence of infection is due to waning immunity after the receipt of two doses of the BNT162b2 vaccine is unclear.

Methods

We conducted a 6-month longitudinal prospective study involving vaccinated health care workers who were tested monthly for the presence of anti-spike IgG and neutralizing antibodies. Linear mixed models were used to assess the dynamics of antibody levels and to determine predictors of antibody levels at 6 months.

Results

The study included 4868 participants, with 3808 being included in the linear mixed-model analyses. The level of

SUBMITTER: Levin EG 

PROVIDER: S-EPMC8522797 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature