Newly approved IV acetaminophen in Canada: Switching from oral to IV acetaminophen. Is IV worth the price difference? A systematic review.

ABSTRACT:

Context

The use of intravenous acetaminophen leads to meaningful health cost increases for paediatric institutions. Therefore, strict criteria for intravenous acetaminophen administration are needed.

Objective

To undertake a systematic review of available evidence comparing oral versus intravenous acetaminophen use in children.

Method

A systematic literature search was conducted on five databases. All prospective interventional studies comparing intravenous to oral acetaminophen in patients <18 years old were included. Data collection and analysis were done according to PRISMA guidelines.

Results

Among 6,417 retrieved abstracts, 29 full-text articles were assessed of which 3 were retained. (1) Pharmacokinetic: Oral bioavailability (72% with a high inter-

SUBMITTER: Ulrich M 

PROVIDER: S-EPMC8522831 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature