The importance of age in compositional and functional profiling of the human intestinal microbiome.

ABSTRACT: The intestinal microbiome plays a central role in human health and disease. While its composition is relatively stable throughout adulthood, the microbial balance starts to decrease in later life stages. Thus, in order to maintain a good quality of life, including the prevention of age-associated diseases in the elderly, it is important to understand the dynamics of the intestinal microbiome. In this study, stool samples of 278 participants were sequenced by whole metagenome shotgun sequencing and their taxonomic and functional profiles characterized. The two age groups, below65 and above65, could be separated based on taxonomic and associated functional features using Multivariate Association of Linear Models. In a second approach, through machine learning, biomarkers connecting the intes

SUBMITTER: Herzog EL 

PROVIDER: S-EPMC8523055 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature