Comprehensive analysis of lectin-glycan interactions reveals determinants of lectin specificity.

ABSTRACT: Lectin-glycan interactions facilitate inter- and intracellular communication in many processes including protein trafficking, host-pathogen recognition, and tumorigenesis promotion. Specific recognition of glycans by lectins is also the basis for a wide range of applications in areas including glycobiology research, cancer screening, and antiviral therapeutics. To provide a better understanding of the determinants of lectin-glycan interaction specificity and support such applications, this study comprehensively investigates specificity-conferring features of all available lectin-glycan complex structures. Systematic characterization, comparison, and predictive modeling of a set of 221 complementary physicochemical and geometric features representing these interactions highlighted specifici

SUBMITTER: Mattox DE 

PROVIDER: S-EPMC8523061 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature