Identifying modifiable risk factors of lung cancer: Indications from Mendelian randomization.

ABSTRACT:

Background

Lung cancer is the major cause of mortality in tumor patients. While its incidence rate has recently declined, it is still far from satisfactory and its potential modifiable risk factors should be explored.

Methods

We performed a two-sample Mendelian randomization (MR) study to investigate the causal relationship between potentially modifiable risk factors (namely smoking behavior, alcohol intake, anthropometric traits, blood pressure, lipidemic traits, glycemic traits, and fasting insulin) and lung cancer. Besides, a bi-directional MR analysis was carried out to disentangle the complex relationship between different risk factors. Inverse-variance weighted (IVW) was utilized to combine the estimation for each SNP. Cochrane's Q value was used to evaluate heterogene

SUBMITTER: Ding J 

PROVIDER: S-EPMC8523078 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature