Microglia and CD206⁺ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.

ABSTRACT: Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in neurodegenerative disorders remain elusive, particularly for activated CD11c⁺ microglia and BAMs. In this study, we conducted a comprehensive fate-mapping analysis of murine microglia and BAMs and their turnover kinetics during Alzheimer's disease (AD) progression. We used a novel inducible AD mouse model to investigate the contribution of bone marrow (BM) cells to the pool of fetal-derived brain macrophages during the development of AD. We demonstrated that microglia remain a remarkably stable embryonic-derived population even duri

SUBMITTER: Wu X 

PROVIDER: S-EPMC8523151 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature