Risk factors for poor prognosis in children and adolescents with COVID-19: A systematic review and meta-analysis.

ABSTRACT:

Background

This study provides the first systematic review and meta-analysis to identify the predictors of unfavorable prognosis of COVID-19 in children and adolescents.

Methods

We searched literature databases until July 2021 for studies that investigated risk factors for unfavorable prognosis of children and adolescents with COVID-19. We used random-effects models to estimate the effect size with 95% confidence interval (CI).

Findings

We identified 56 studies comprising 79,104 individuals. Mortality was higher in patients with multisystem inflammatory syndrome (MIS-C) (odds ratio [OR]=58.00, 95% CI 6.39-526.79) and who were admitted to intensive care (OR=12.64, 95% CI 3.42-46.68). Acute respiratry distress syndrme (ARDS) (OR

SUBMITTER: Shi Q 

PROVIDER: S-EPMC8523335 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature