Searching for improvements in predicting human eye colour from DNA.

ABSTRACT: Increasing understanding of human genome variability allows for better use of the predictive potential of DNA. An obvious direct application is the prediction of the physical phenotypes. Significant success has been achieved, especially in predicting pigmentation characteristics, but the inference of some phenotypes is still challenging. In search of further improvements in predicting human eye colour, we conducted whole-exome (enriched in regulome) sequencing of 150 Polish samples to discover new markers. For this, we adopted quantitative characterization of eye colour phenotypes using high-resolution photographic images of the iris in combination with DIAT software analysis. An independent set of 849 samples was used for subsequent predictive modelling. Newly identified candidates and 11

SUBMITTER: Kukla-Bartoszek M 

PROVIDER: S-EPMC8523394 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature