Molecular epidemiology of coxsackievirus A16 circulating in children in Beijing, China from 2010 to 2019.

ABSTRACT:

Background

Coxsackievirus A16 (CVA16) is one of the major etiological agents of hand, foot and mouth disease (HFMD). This study aimed to investigate the molecular epidemiology and evolutionary characteristics of CVA16.

Methods

Throat swabs were collected from children with HFMD and suspected HFMD during 2010-2019. Enteroviruses (EVs) were detected and typed by real-time reverse transcription-polymerase chain reaction (RT-PCR) and RT-PCR. The genotype, evolutionary rate, the most recent common ancestor, population dynamics and selection pressure of CVA16 were analyzed based on viral protein gene (VP1) by bioinformatics software.

Results

A total of 4709 throat swabs were screened. EVs were detected in 3180 samples and 814 were CVA16 positive. More than 81% of CVA16-posi

SUBMITTER: Hu YF 

PROVIDER: S-EPMC8523403 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature