Context value updating and multidimensional neuronal encoding in the retrosplenial cortex.

ABSTRACT: The retrosplenial cortex (RSC) has diverse functional inputs and is engaged by various sensory, spatial, and associative learning tasks. We examine how multiple functional aspects are integrated on the single-cell level in the RSC and how the encoding of task-related parameters changes across learning. Using a visuospatial context discrimination paradigm and two-photon calcium imaging in behaving mice, a large proportion of dysgranular RSC neurons was found to encode multiple task-related dimensions while forming context-value associations across learning. During reversal learning requiring increased cognitive flexibility, we revealed an increased proportion of multidimensional encoding neurons that showed higher decoding accuracy for behaviorally relevant context-value associations. Chemo

SUBMITTER: Sun W 

PROVIDER: S-EPMC8523535 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature