Self-reactivity controls functional diversity of naive CD8⁺ T cells by co-opting tonic type I interferon.

ABSTRACT: The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8⁺ T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5^loLy6C^-, CD5^hiLy6C^-, and CD5^hiLy6C⁺ cells. CD5^hiLy6C⁺ cells differ from CD5^loLy6C^- and CD5^hiLy6C^- cells in terms of gene expression profiles and functional properties. Moreover, CD5^hiLy6C⁺ cells demonstrate more extensive antigen-specific expansion upon

SUBMITTER: Ju YJ 

PROVIDER: S-EPMC8523551 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature