Spontaneous traveling waves naturally emerge from horizontal fiber time delays and travel through locally asynchronous-irregular states.

ABSTRACT: Studies of sensory-evoked neuronal responses often focus on mean spike rates, with fluctuations treated as internally-generated noise. However, fluctuations of spontaneous activity, often organized as traveling waves, shape stimulus-evoked responses and perceptual sensitivity. The mechanisms underlying these waves are unknown. Further, it is unclear whether waves are consistent with the low rate and weakly correlated "asynchronous-irregular" dynamics observed in cortical recordings. Here, we describe a large-scale computational model with topographically-organized connectivity and conduction delays relevant to biological scales. We find that spontaneous traveling waves are a general property of these networks. The traveling waves that occur in the model are sparse, with only a small fracti

SUBMITTER: Davis ZW 

PROVIDER: S-EPMC8523565 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature