Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway.

ABSTRACT: G-protein-coupled receptors (GPCRs) are a target for over 34% of current drugs. The calcium-sensing receptor (CaSR), a family C GPCR, regulates systemic calcium (Ca²⁺) homeostasis that is critical for many physiological, calciotropical, and noncalciotropical outcomes in multiple organs. However, the mechanisms by which extracellular Ca²⁺ (Ca²⁺_ex) and the CaSR mediate networks of intracellular Ca²⁺-signaling and players involved throughout the life cycle of CaSR are largely unknown. Here we report the first CaSR protein-protein interactome with 94 novel putative and 8 previously published interactors using proteomics. Ca²⁺_ex promotes enrichment of 66% of the identified CaSR interactors, pertaining to Ca²⁺

SUBMITTER: Gorkhali R 

PROVIDER: S-EPMC8523568 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature